Screening for Hypercholesterolemia in Children Using Dried Blood Spot (CHOLESPOT)

  • End date
    Jun 18, 2024
  • participants needed
  • sponsor
    Hospices Civils de Lyon
Updated on 29 June 2022
blood test
cholesterol measurement
Accepts healthy volunteers



Heterozygous Familial Hypercholesterolemia (HeFH) is a common genetic disease responsible for premature atherosclerosis. Therefore, early diagnosis and initiation of a treatment early as at the age of eight years old are recommended to reduce cardiovascular risk. Child-parent screening based on plasma LDL-cholesterol has been proposed to identify patients with hypercholesterolemia. However, in children, venipuncture is often an obstacle for screening. This study aims to evaluate the performance and feasibility of a dried blood spot collection to screen hypercholesterolemia.

Method: The lipid profile of 30 healthy and 30 hypercholesterolemic patients will be determined using Dried Blood Spot (DBS) collection and veinipuncture.

The study is conducted in accordance with the principles of the Declaration of Helsinki. The children, their parents and patients will be informed about this study according to the French bioethics law and will be included only after their agreement


  • to evaluate the performance of the determination of total and LDL-cholesterol using a dried blood spot collection to screen hypercholesterolemia
  • to evaluate the feasibility of a dried blood spot collection to screen hypercholesterolemia

Condition Hypercholesterolemia
Treatment Blood test
Clinical Study IdentifierNCT05191355
SponsorHospices Civils de Lyon
Last Modified on29 June 2022


Yes No Not Sure

Inclusion Criteria

patients/kindreds in family with a documented history of hypercholesterolemia
healthy subjects for controls

Exclusion Criteria

refusal to participate in the study
For control patients: to have a known dyslipidemia
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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