Effect of PD-1 /PD-L1 Inhibitor Therapy Before Liver Transplantation on Acute Rejection After Liver Transplantation in Patients With Hepatocellular Carcinoma

  • STATUS
    Recruiting
  • End date
    Sep 14, 2023
  • participants needed
    30
  • sponsor
    Beijing Tsinghua Chang Gung Hospital
Updated on 14 June 2022

Summary

This study is a single-center, prospective, non-interventional cohort study based on the real world data.In this study, 30 patients with a history of PD-1/PD-L1 monotherapy prior to liver transplantation and 30 patients without a history of PD-1/PD-L1 monotherapy prior to liver transplantation were recruited from the group of patients with hepatocellular carcinoma who had undergone allogeneic liver transplantation.Collected patient data included demographics, oncology and immunotherapy history, evaluated index before liver transplantation, laboratory, pathological and imaging results at specific time points after transplantation (1 week, 2 weeks, 3 weeks, 4 weeks, 12 weeks, 16 weeks, 24 weeks), as well as the occurrence of acute rejection (AR) , grading of severity, and anti-rejection treatment plan at the same time. Endpoints included relapse-free survival and overall survival (OS). These data aims to assess: 1) the incidence of acute rejection after liver transplantation in patients with hepatocellular carcinoma; 2) the time of acute rejection, Banff classification, and acute rejection-related mortality after liver transplantation in patients with hepatocellular carcinoma; 3) the cellular immune function after liver transplantation;; 4) the dose and drug concentration of tacrolimus after liver transplantation in patients with hepatocellular carcinoma; and 5) the overall survival (OS) and relapse-free survival(RFS) after liver transplantation in patients with hepatocellular carcinoma.

Details
Condition Hepatocellular Carcinoma, Acute Rejection
Clinical Study IdentifierNCT05411926
SponsorBeijing Tsinghua Chang Gung Hospital
Last Modified on14 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

age between 18 and 70 years
Eastern Cooperative Oncology Group (ECOG) performance score ≤3
voluntarily participate, totally understand in the study and sign the Informed Consent Form (ICF)
hepatopathology confirmed hepatocellular carcinoma after liver transplantation, 5)patients with hepatocellular carcinoma treated with PD1/PD-L1 monoclonal antibody prior to liver transplantation
)PD-1/PD-L1 monotherapy needs to be used ≥ 2 times (The patients were divided into
observation and control group according to whether received PD-1/PD-L1 monoclonal antibody
treatment before liver transplantation)

Exclusion Criteria

patients with incomplete clinicopathological data
post-transplantation ≥6months
PD-1/PD-L1 monotherapy required for oncological reasons after liver transplantation
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