Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy (CSS)

  • End date
    Jun 13, 2023
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de Nīmes
Updated on 13 June 2022
amyloid deposition


Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the majority of patients. In that study, cerebellar SS was associated with a higher number of supratentorial lobar and superficial cerebellar macrobleeds (although cerebellar SS was not directly located adjacent to these cerebellar macrobleeds). It is unclear if cerebellar SS is caused by in situ leakage of cerebellar leptomeningeal vessels or rather represents hemorrhagic diffusion from cerebellar parenchymal micro/macrobleeds or from supratentorial bleeding sources via the tentorium cerebelli (TC).

Condition Cerebral Amyloid Angiopathy, Siderosis
Treatment None, pure observational study
Clinical Study IdentifierNCT05394636
SponsorCentre Hospitalier Universitaire de Nīmes
Last Modified on13 June 2022


Yes No Not Sure

Inclusion Criteria

CAA patients (according to the modified Boston criteria)
with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS

Exclusion Criteria

Patients with recent trauma
Patients with anticoagulation treatment
Patients with pathological blood coagulation tests (activated partial thromboplastin time [aPTT] ratio=patient's aPTT/normal control aPTT] >1.2; or partial thromboplastin time [PTT] <75%) or platelet count (<100 x 109/L)
Patients with inflammatory CAA
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