Effects of a 12-week Strength Training Program in Women With Myotonic Dystrophy Type 1

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    Élise Duchesne
Updated on 20 June 2022
Elise Duchesne, Ph.D.
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Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (6.3 mi away) Contact
myotonic dystrophy


20 women with myotonic dystrophy type 1 (DM1) will complete a 12-week lower-limb strength training program. The training program consist of 3 series of 6 to 8 maximal repetitions of 5 different exercises: Leg extension, leg press, hip abduction, squat and plantar flexion. Training sessions will be closely supervise and take place twice a week. It is hypothesize that the training program will induce muscular hypertrophy despite the genetic defect. The training program should also have positive effects on function. The participants will be evaluated at baseline, week 6, week 12, month 6 and month 9 to quantify the effects of the training program and if these effects will be maintained over time.

Condition Myotonic Dystrophy 1
Treatment Training program
Clinical Study IdentifierNCT05400629
SponsorÉlise Duchesne
Last Modified on20 June 2022


Yes No Not Sure

Inclusion Criteria

DM1 diagnosis must be confirmed by genetic analysis
Women sex, aged between 30 and 65 years old
Be able to walk without assistance
Consent of the neurologist must be given to participate in this study
Must reside in the Saguenay-Lac-St-Jean region
Subjects must be able to give their consent freely and voluntarily

Exclusion Criteria

Patients with any other form of muscular dystrophy are excluded
Any contraindication for strenuous exercise or muscle biopsy
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