Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyses A1 Milk

  • End date
    Dec 9, 2023
  • participants needed
  • sponsor
    University of Turku
Updated on 9 June 2022
gastrointestinal symptoms
Accepts healthy volunteers


The aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from milk. Research hypotheses are: 1) Protein hydrolyzed milk is as tolerated or better tolerated than A2 milk, and 2) Lactose is the main causative agent of stomach symptoms in milk-sensitive individuals.

Condition Milk Intolerance
Treatment Dietary intervention
Clinical Study IdentifierNCT05305391
SponsorUniversity of Turku
Last Modified on9 June 2022


Yes No Not Sure

Inclusion Criteria

Perceive disturbing gut symptoms from regular milk
Commits to the research diet for the whole research period
Age: 18-65
BMI: 18.5-30
Healthy (normal kidney, liver and thyroid function and self-reported)

Exclusion Criteria

Milk allergy
Regular medication (other than contraceptives) or medication affecting the gut
Recent course of antibiotics (< 3 months prior the study)
Pregnancy or lactation
Diagnosed bowel disease
Clear my responses

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What happens next?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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