Multimodal Correction of Post-stroke Motor and Cognitive Impairments

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Updated on 4 October 2022


The aim of the study is the development and scientific substantiation of the effectiveness and safety of multimodal rehabilitation technology using innovative digital technologies, biofeedback (BFB), virtual reality (VR), neurointerface for the restoration of stato-locomotor disorders, neuromuscular control of upper limb movements and cognitive functions in patients with ischemic stroke (IS) in different recovery periods with rehabilitation risks control in outpatient clinic.


The object of the study The study will include 90 patients (men and women) with the diagnosis of ischemic stroke (IS) in the early recovery (up to 6 months) and late recovery (6-12 months) periods with stato-locomotor disturbances, dysfunction (violation of neuromuscular movement control) of the upper limb (UL), mild or moderate cognitive impairment.

Patients will be randomly assigned to one of three experimental groups - 2 main groups in the early (30 patients) and in the late recovery period (30 patients) of IS and 1 comparison group (30 patients) in the early and late recovery periods of IS.

Each participant of the study will be assigned an ordinal number. Patients of the 1st and 2nd main groups are planned to undergo a rehabilitation course with multimodal correction, depending on the severity of functional and neuropsychological disturbances with the use of FBF-stabilometric training, cognitive-motor training with double and triple tasks in a virtual environment, functional individually programmed stimulation of antagonist muscles of the lower limb (FES), training of subject-manipulative activity for the restoration of fine hand movements on the glove simulator "SensoRehab"; when severe and moderate paresis of the upper limb, the neurointerface "Exokist-3" with EEG registration will be used.

The mode of application of multimodal correction technology: 15 procedures, 2-3 times a week, the duration of the course is 5-8 weeks. The total duration of one procedure is 2-3 hours a day.

Multimodal correction technology will not be included in the rehabilitation program of patients in the comparison group.

Condition Stroke Rehabilitation
Treatment Conventional Rehabilitation (CR), Multimodal technology (MT)
Clinical Study IdentifierNCT05391919
SponsorMoscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Men or women aged 45 to 70 years after a first-onset IS, early (1-6 months), late recovery (6-12 months) periods
Supratentorial IS according to MRI of the brain
The severity of UL paresis ranged from a score of 4 to 3 according to the Medical Research Council Scale (MRCS).20
Spasticity of 2 points or less by the Modified Ashworth Scale (MAS)
Cognitive function more than 20 points on the Montreal Cognitive Assessment (MoCA)
Affective disorders score less than 11 on the Hospital Anxiety and Depression Scale (HADS)
The patient's ability and willingness to comply with the requirements of this protocol

Exclusion Criteria

Concomitant neurological diseases causing decreased muscle strength or increased muscle tone in the UL (e.g., cerebral palsy, brain injury)
Clinically significant limitation of the passive movement amplitude in the joints of the investigated hand, pronounced contracture and deformities of the upper extremity
Use of other DIT, BFB techniques to restore impaired UL function within 30 days prior to the patient Inclusion Visit
Severe visual impairment, decreased visual acuity of less than 0.2 in the worst eye according to the Golovin-Sivtsev Table24
Sensory aphasia, gross motor aphasia
Recurrent stroke
Unstable angina and/or heart attack in previous month
Uncontrolled arterial hypertension
Somatic diseases in decompensation stage
Thrombosis of deep and superficial veins of the lower extremities
The presence of left-handedness in the patient according to the Edinburgh manual asymmetry questionnaire
Alcohol abuse, medical marijuana use or soft drug abuse within the 12 months prior to the Inclusion Visit
Any medical condition, including mental disease or epilepsy that could affect the interpretation of study results, the study procedures or patient safety
Pregnancy. 16. Lactation
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