Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic KIDNEY Disease (LAA-KIDNEY)
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- STATUS
- Recruiting
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- End date
- Jan 14, 2026
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- participants needed
- 430
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- sponsor
- Prof. Dr. med. Ingo Eitel
Summary
In the proposed event driven trial, LAA closure devices will be compared in a 1:1 randomization to best medical care in AF patients at high risk of stroke and bleeding with ESKD. The trial will allow the use of the CE marked and clinically used LAA device Amplatzer Cardiac Plug and/or Amulet and all approved medical therapies in AF patients with ESKD including vitamin-K antagonists (VKA), NOACs as well as antiplatelet agents or no anticoagulation in excessive bleeding risk.
Description
The purpose of the current study is to evaluate the clinical benefit of percutaneous catheter-based left atrial appendage (LAA) closure in patients with non-valvular atrial fibrillation (NVAF) and end-stage renal failure.
Details
| Condition | Non-valvular Atrial Fibrillation (NVAF): Paroxysmal, Persistent, Permanent |
|---|---|
| Treatment | Left atrial appendage closure |
| Clinical Study Identifier | NCT05204212 |
| Sponsor | Prof. Dr. med. Ingo Eitel |
| Last Modified on | 9 June 2022 |
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