Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis

  • STATUS
    Recruiting
  • End date
    Mar 31, 2023
  • participants needed
    80
  • sponsor
    Kangbuk Samsung Hospital
Updated on 7 June 2022
cirrhosis

Summary

The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.

Description

The aim of this prospective study is to collect data on patients with liver cirrhosis and to investigate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis. If patients agree to participate in this clinical trial, the patients' data (such as age, sex, height, weight, nutrition status [RFH-NPT], history of medication, laboratory findings, endoscopic findings, and radiologic findings) will be collected in a research database. Renal injury was measured using conventional and novel serum biomarkers (serum creatinine, cystatin-C, neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, and interleukin-18. Sarcopenia was evaluated using skeletal muscle index on abdominal computed tomography. Frailty was measured using Liver Frailty Index. The research database will be updated to include data on patients' disease outcomes and follow-up care.

Details
Condition Cirrhosis, Kidney Injury, Sarcopenia, Frailty
Clinical Study IdentifierNCT05389280
SponsorKangbuk Samsung Hospital
Last Modified on7 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Liver cirrhosis
aged over 20 years

Exclusion Criteria

serum creatinine >1.5 mg/dL
on dialysis
liver transplant
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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