Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis

  • End date
    Mar 31, 2023
  • participants needed
  • sponsor
    Kangbuk Samsung Hospital
Updated on 7 June 2022


The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.


The aim of this prospective study is to collect data on patients with liver cirrhosis and to investigate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis. If patients agree to participate in this clinical trial, the patients' data (such as age, sex, height, weight, nutrition status [RFH-NPT], history of medication, laboratory findings, endoscopic findings, and radiologic findings) will be collected in a research database. Renal injury was measured using conventional and novel serum biomarkers (serum creatinine, cystatin-C, neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, and interleukin-18. Sarcopenia was evaluated using skeletal muscle index on abdominal computed tomography. Frailty was measured using Liver Frailty Index. The research database will be updated to include data on patients' disease outcomes and follow-up care.

Condition Cirrhosis, Kidney Injury, Sarcopenia, Frailty
Clinical Study IdentifierNCT05389280
SponsorKangbuk Samsung Hospital
Last Modified on7 June 2022


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Inclusion Criteria

Liver cirrhosis
aged over 20 years

Exclusion Criteria

serum creatinine >1.5 mg/dL
on dialysis
liver transplant
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