Radiofrequency Ablation With Gradual Radiofrequency Energy Increment for Hepatocellular Carcinoma Treatment

  • End date
    Aug 30, 2023
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 2 July 2022
hepatocellular carcinoma


To evaluate local tumor progression rate at 12 months after percutaneous radiofrequency ablation with gradual radiofrequency energy delivery mode with Octopus electrodes in patients with hepatocellular carcinoma.

Condition Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Liver Disease
Treatment Radiofrequency ablation using gradual RF energy delivery with Octopus electrodes, Radiofrequency ablation using gradual radiofrequency energy delivery with Octopus electrodes
Clinical Study IdentifierNCT05397860
SponsorSeoul National University Hospital
Last Modified on2 July 2022


Yes No Not Sure

Inclusion Criteria

Child-Pugh Class A or B
chronic hepatitis B or liver cirrhosis
contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) within 60 days of scheduled radiofrequency ablation (RFA) date
clinically diagnosed hepatocellular carcinoma (HCC), equal or less than 4 cm

Exclusion Criteria

number of HCC, equal or more than 3
largest tumor size over 4 cm
Child-Pugh class C
presence of vascular invasion by HCC
platelet count less than 40,000 per mm3 or International Normalized Ratio (INR) prolongation over 50%
presence of extrahepatic metastasis
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