3DPCT Combined With CT Guided RISI in the Treatment of Thoracic Malignant Tumors

  • STATUS
    Recruiting
  • End date
    Apr 30, 2026
  • participants needed
    30
  • sponsor
    Peking University Third Hospital
Updated on 16 June 2022

Summary

The main technical difficulties in radioactive iodine-125 seed implantation (RISI) lie in the complexity of operation and the control of operation quality. The current data shows that under the combined guidance of 3D-printing template and CT, the accuracy of RISI has been significantly improved, and the actual target dose could meet the design requirements of preoperative plan.

At present, 3D printing templates (3DPT) are divided into non-coplanar templates (3DPNCT) and coplanar templates (3DPCT). In clinical practice, due to the complex technical requirements, high production cost and long printing time of 3DPNCT, a considerable number of patients can also complete the treatment with 3DPCT. Moreover, compared with 3DPNCT, 3DPCT has the advantages of accurate needle path control, fast needle path adjustment, convenient for intraoperative real-time optimization, without waiting for printing time, easy for doctors to master, lower cost than 3DPNCT, and easy to carry out at the grass-roots level. Therefore, this study intends to explore 3DPCT technology to further clarify: (1) the accuracy of 3DPCT assisted CT guided RISI in the treatment of thoracic malignant tumors; (2) the short-term efficacy and toxicity of 3DPCT assisted CT guided RISI in the treatment of thoracic malignant tumors.

Details
Condition Radioactive Iodine-125 Brachytherapy, Thoracic Cancer, 3D Printing Coplanar Template, Nuclear Radiation Effects
Treatment Radioactive seed brachytherapy
Clinical Study IdentifierNCT05351268
SponsorPeking University Third Hospital
Last Modified on16 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Pathological diagnosis of malignant tumor of chest, lesion diameter less than 7 cm
There is no extensive systemic metastasis or although there is metastasis, the metastasis have been controlled by early treatment
No bleeding tendency, anticoagulant therapy and / or antiplatelet coagulation drugs should be stopped for at least 1 week before treatment
No serious or uncontrolled underlying diseases (such as severe or uncontrolled hypertension, diabetes, cardiovascular and cerebrovascular diseases and organ dysfunction) are found
There is a suitable puncture path, and the therapeutic dose is expected to be achieved
KPS > 70, expected to tolerate puncture / seed implantation, and expected survival time greater than 3 months

Exclusion Criteria

Severe impairment of lung function (such as FEV1 < 40% predicted value, FVC < 50% predicted value, DLCO < 40% predicted value)
High risk of skin invasion and ulceration at the puncture site before treatment
There is a large range of liquefaction and necrosis in the lesion, and the expected seed distribution would be poor
Pregnant women, lactating women and mentally ill patients
The patient with poor compliance and unable to complete the treatment
Other conditions of the researchers who think it is not suitable to participate in this clinical trial
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