Cohort Study of Patients With Hepatocellular Carcinoma and Circulating Tumor DNA Monitoring of Chemoembolization (Mona-Lisa)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2024
  • participants needed
    167
  • sponsor
    University Hospital, Rouen
Updated on 4 June 2022

Summary

Cohort study to assess the impact of ctDNA detection in the follow-up and management of patients with hepatocellular carcinoma treated by TACE

Description

The incidence of hepatocellular carcinoma (HCC) has increased significantly over the past 30 years.

The majority of HCCs present at an intermediate stage, ineligible for a curative surgical approach and the reference treatment in this situation corresponds to a palliative locoregional treatment of Transarterial chemoembolization (TACE). This treatment modality can be repeated several times and the interval between each session as well as the modalities to evaluate the efficacy of this procedure remain poorly codified. This evaluation is currently based on imaging performed at one month (M1) (MRI and/or CT scan) more or less associated with the study of the variation of the alphafetoprotein level measured before (baseline) and after (M1) the treatment. However, these evaluation tools have many limitations and remain imperfect in predicting response to treatment.

In this context, liquid biopsy, which is experiencing significant growth in oncology, could be a promising tool. It is characterized by the detection of tumor elements in the bloodstream such as circulating tumor DNA (ctDNA). Several studies have successfully demonstrated the diagnostic or prognostic value of ctDNA in patients followed for HCC.

the aim of our study is to evaluate the impact of ctDNA detection in the follow-up of patients treated by TACE.

Details
Condition Circulating Tumor DNA, Hepatocellular Carcinoma Non-resectable, Transarterial Chemoembolization
Treatment DNA
Clinical Study IdentifierNCT05390112
SponsorUniversity Hospital, Rouen
Last Modified on4 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age ≥ 18 years
HCC diagnosed on consensus radiological criteria in cirrhotic patients (EASL-EORTC 2012): helical CT or MRI with triple arterial, portal, and late acquisition. The diagnosis is based on the presence of hypervascularization at the early arterial time (wash-in) with wash-out (hypodensity or hypointensity compared with non-tumor liver parenchyma) at the portal phase or late phase compared with non-tumor parenchyma
Histologically diagnosed HCC in the absence of an imaging diagnosis
Patient with a first TACE (naive) or not, regardless of the number of previous procedures
Patient naïve or on a new line of oncological treatment, regardless of the number of previous lines of treatment
Treatment decision validated by the digestive oncology staff
Patient having read and understood the information letter and signed the informed consent
Patient follow-up performed at the Charles Nicolle University Hospital in Rouen

Exclusion Criteria

Other active cancer or hematological malignancy, currently being treated
Patient not affiliated to the social security system
Pregnant woman or woman in labour or breastfeeding
Person deprived of liberty by an administrative or judicial decision
Person placed under court protection
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