PREcision Medicine in Cancer in Odense, Denmark (PRECODE)

  • days left to enroll
  • participants needed
  • sponsor
    Odense University Hospital
Updated on 3 June 2022


The traditional approach to cancer treatment has changes from using drugs approved for the specific cancer diagnosis to a tumor agnostic approach when treating solid tumors. How often will tumor biopsy and genomic profiling in patients with advanced solid tumors with no further evidence based treatment options result in biomarker-driven targeted treatment ? Feasibility of the investigation of patients and median turnaround time from biopsy to available genomic profile is evaluated.


Genomic profiling in patients with advanced solid tumors and no further evidence based treatment options is a newer approach. The frequency of genomic alterations varies between individual tumor types and the actionability of somatic variants are different but evolves in line with the development of new targeted drugs. In accordance with expected short survival short assessment time is important to minimize the risk of patient detoriation during the investigation. A fresh biopsy from lesions in progression is preferred for analysis. To minimize the duration of the genomic profiling a genpanel analysis covering the most frequent oncogene targets is preferred.

The primary objective is to evaluate the feasibility of the investigational procedures. The secondary objective is to investigate how often genomic changes in tumor tissue gives rise to a targeted treatment offer and to evaluate the clinical benefit using the Growth Modulation Index.

Condition Metastatic Solid Tumor
Treatment Genomic profiling
Clinical Study IdentifierNCT05385081
SponsorOdense University Hospital
Last Modified on3 June 2022


Yes No Not Sure

Inclusion Criteria

Written informed consent
Age ≥ 18 years
Diagnosis of advanced solid tumors
Evidence based treatment options are exhausted
Performance Status 0-2
Adequate organ function
Life expectancy of at least 3 months

Exclusion Criteria

• inclusions criteria not met
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