Labor Induction in Preeclampsia High-risk Women (FORECAST-IOL)

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Chinese University of Hong Kong
Updated on 13 June 2022
perinatal morbidity


Preeclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality. This pregnancy-specific disorder poses to both pregnant women and their offspring an increased risk of immediate and long-term health problems. The study team is conducting a study entitled "FORECAST" (Implementation of First-trimester Screening and preventiOn of pREeClAmpSia Trial) and established the infrastructure for the first-trimester "screen and prevent" program for preterm PE. However, there is no established evidence regarding the benefit of scheduled labor induction versus expectant management among women identified as high-risk for PE with uncomplicated pregnancy at term. The investigators postulate that induction of labor at 39 weeks' gestation may possibly be an effective intervention to reduce placental complications in women with uncomplicated pregnancy by 39 weeks at high-risk PE women.

Condition Pre-Eclampsia, Induction of Labor
Treatment Induction of Labor, Induction of Labor
Clinical Study IdentifierNCT05056467
SponsorChinese University of Hong Kong
Last Modified on13 June 2022


Yes No Not Sure

Inclusion Criteria

Age no less than 18 years
Singleton pregnancy with cephalic presentation and no contraindication to vaginal delivery
Live fetus
Screened high-risk for PE
Informed and written consent

Exclusion Criteria

Multiple pregnancy
Pregnant women who plan to have Cesarean delivery
Pregnancies complicated by the major fetal abnormality
Women who are severely ill, those with learning difficulties, or serious mental illness
Pregnant women with medical, obstetric, or fetal complications or any other indications for delivery before 39 weeks' gestation
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