Prospective Longitudinal Effects of Intra-articular Corticosteroid Injection on Synovial Fluid Oxygen (POLO)
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- STATUS
- Recruiting
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- End date
- Apr 29, 2024
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- participants needed
- 10
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- sponsor
- University of Oxford
Summary
Inflammatory arthritis such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are characterized by synovial inflammation of joints, potentially leading to joint destruction and functional disability. Inflamed joints have lower oxygen levels. Studying how oxygen level within the joint affect inflammation may lead to new treatments for patients with arthritis. Anti-inflammatory corticosteroid injection into the joint is well tolerated and widely used in clinical practice but its effects on oxygen level within joints is unknown. Therefore, patients who require corticosteroid injection into the joint as routine clinical care will have biological samples collected before and after the injection. This will give new information to put into context the biological effects within the joint, and accelerate development of new treatment approaches in the future.
Details
| Condition | Rheumatoid Arthritis, Psoriatic Arthritis |
|---|---|
| Clinical Study Identifier | NCT04804449 |
| Sponsor | University of Oxford |
| Last Modified on | 29 May 2022 |
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