Efficacy and Safety of Metformin Versus Empagliflozin on Chronic Kidney Disease Progression

  • End date
    Jun 27, 2024
  • participants needed
  • sponsor
    Tanta University
Updated on 27 May 2022


This randomized controlled trial aims at evaluating the efficacy and safety of the antidiabetics metformin versus empagliflozin on chronic kidney disease (CKD) progression in patients with CKD stages 2 or/and 3.

Condition Renal Insufficiency, Chronic
Treatment Metformin, Empagliflozin, Standard therapy
Clinical Study IdentifierNCT05373680
SponsorTanta University
Last Modified on27 May 2022


Yes No Not Sure

Inclusion Criteria

Patients with mild or/and moderate chronic kidney disease (stages 2 or/and 3, estimated glomerular filtration rate (eGFR) between 30-89 ml/min/1.73 m2) at the time of the baseline visit
Patients with and without type 2 diabetes
Patients with or without proteinuria
Age: ≥ 18 years

Exclusion Criteria

Type 1 diabetes
Patients with eGFR ˂30 ml/min/1.73 m2
Patients with known hepatic cell failure
Decompensated heart requiring acute management
Active malignancy
Planned coronary or surgical interventions
Known hypersensitivity to study medications
Chronic inflammation, trauma, or infection
Pregnant or lactating women
Patients already on metformin or a sodium-glucose cotransporter-2 (SGLT2) inhibitor
Any of the study treatments labeled contraindications
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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