Evaluation of Plasma Concentrations of Intravenous Lidocaine and Epidural Ropivacaine When Used in Combination in Major Abdominal Surgery (LARA)

  • STATUS
    Recruiting
  • End date
    Apr 26, 2023
  • participants needed
    50
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Updated on 26 May 2022

Summary

Thoracic epidural analgesia (TEA) is the gold standard analgesia of the laparotomy in major abdominal surgery and can be associated with intravenous lidocaine or subtituted by intravenous lidocaine when TEA is contraindicated and in order to reduce the use of the morphinics in the perioperative period.

Side effects can be paralytic ileus or nausea and vomiting and delay the enhanced recovery after surgery.

Intravenous lidocaine and TEA share several properties like anti hyperalgesia, anti inflammatory effect, intestinal process, anti tumoral effect… which suggests an additive effect of their combination that was not studied yet.

Details
Condition Abdominal Surgery by Laparotomy, Thoracic Epidural Analgesia, Analgesia, Lidocaine Adverse Reaction
Treatment Blood sample, ropivacaine, Lidocain
Clinical Study IdentifierNCT05368753
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on26 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Abdominal surgery by laparotomy

Exclusion Criteria

laparoscopic abdominal surgery
TEA contraindication
ropivacaine contraindication
intravenous lidocaine contraindication
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