Premedication With Labetalol Versus Metoprolol for Controlled Hypotension During Endoscopic Nasal Surgeries

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    Damanhour Teaching Hospital
Updated on 16 August 2022


Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased risk of complications, increased operation time, and increased blood loss. There are several pharmacological techniques for the appropriate control of intraoperative bleeding.

Objectives: To compare the safety and efficacy of oral labetalol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during endoscopic nasal surgeries.

Patients and Methods: This is a randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for endoscopic nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group L, received oral labetalol, and group M, received oral metoprolol.

Condition Hypotension Drug-Induced
Treatment Metoprolol Tartrate Oral Tablet, Labetalol Hydrochloride Oral Tablet
Clinical Study IdentifierNCT05368376
SponsorDamanhour Teaching Hospital
Last Modified on16 August 2022

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