Deafness and Cognition in Middle-aged Adults (SURDICOG)

  • STATUS
    Recruiting
  • End date
    Nov 24, 2025
  • participants needed
    180
  • sponsor
    Assistance Publique - Hôpitaux de Paris
Updated on 16 June 2022
Accepts healthy volunteers

Summary

A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years. The aim of our study was to compare cognitive function between patients with severe and profound hearing loss and patients with normal hearing in patients aged 45 to 64 years.

Description

This case-control study will include 180 middle aged adults (90 cases, 90 healthy controls) matched on sex, age, education level in order to find an association between severe and profound hearing loss and presence of mild cognitive impairment.

90 subjects with severe to profound hearing loss,, with a maximum speech intelligibility of 70% for Fournier's disyllabic words in silence with properly fitted hearing aids could be included. Cognition evaluated on a battery of 5 tests, depression and dependance will be compared to healthy controls with normal hearing on pure-tone audiometry (as function of ISO 7029 reference) The subjects (cases and controls) will be recruited in the ENT consultation from the Cochlear Implant Center (Unité fonctionnelle implants auditifs, Pitié-Salpêtrière Hospital, Head: Dr Isabelle Mosnier)

Details
Condition Mild Cognitive Impairment in Middle-aged Adults
Treatment Cognitive and audiometry evaluation
Clinical Study IdentifierNCT05149742
SponsorAssistance Publique - Hôpitaux de Paris
Last Modified on16 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Cases: Patients aged between 45 to 64 years with severe to profound bilateral post-lingual sensorineural hearing loss with a maximum intelligibility of 70% (disyllabic words) in free-field silence with hearing aids at 60 dB SPL, current in french
Controls: normal hearing subjects matched on age, sex and education level

Exclusion Criteria

Associated disability that prevents the tests from being performed
Past and current history of neurological and psychiatric disorders including meningitis
Psychotropic drug treatment
Vulnerable subject
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