Lesion Contiguity in Very High Power-short Duration Ablation

  • STATUS
    Recruiting
  • End date
    Jun 25, 2023
  • participants needed
    128
  • sponsor
    University of Barcelona
Updated on 25 May 2022
fibrillation
radiofrequency ablation
catheter ablation
pulmonary vein isolation

Summary

This observational trial investigates the effect of very high power-short duration radiofrequency ablation on lesion contiguity as assessed by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Patients with paroxysmal or early persistent atrial fibrillation (AF) scheduled for pulmonary vein isolation (PVI) undergo point-by-point ablation using the QDOT micro catheter applying Qmode+ (90W over 4 seconds). All patients receive an LGE-CMR 3 months after the procedure for ablation lesion assessment. Contiguity of LGE-CMR-detected ablation lesions will be compared with a matched control group of patients that have undergone PVI accomplished by ablation index-guided ablation with 40 W following the CLOSE protocol.

Details
Condition Atrial Fibrillation
Clinical Study IdentifierNCT05368610
SponsorUniversity of Barcelona
Last Modified on25 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

paroxysmal or early persistent (max. 3 months) atrial fibrillation
scheduled for PVI-only catheter ablation

Exclusion Criteria

long-standing persistent atrial fibrillation
previous left atrial ablation
claustrophobia preventing CMR
sever renal insufficiency (GFR >30 ml/min)
gadolinium contrast allergy
presence of implantable devices not compatible with magnetic resonance
pregnancy and lactation
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