Lesion Contiguity in Very High Power-short Duration Ablation

  • End date
    Jun 25, 2023
  • participants needed
  • sponsor
    University of Barcelona
Updated on 25 May 2022
radiofrequency ablation
catheter ablation
pulmonary vein isolation


This observational trial investigates the effect of very high power-short duration radiofrequency ablation on lesion contiguity as assessed by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Patients with paroxysmal or early persistent atrial fibrillation (AF) scheduled for pulmonary vein isolation (PVI) undergo point-by-point ablation using the QDOT micro catheter applying Qmode+ (90W over 4 seconds). All patients receive an LGE-CMR 3 months after the procedure for ablation lesion assessment. Contiguity of LGE-CMR-detected ablation lesions will be compared with a matched control group of patients that have undergone PVI accomplished by ablation index-guided ablation with 40 W following the CLOSE protocol.

Condition Atrial Fibrillation
Clinical Study IdentifierNCT05368610
SponsorUniversity of Barcelona
Last Modified on25 May 2022


Yes No Not Sure

Inclusion Criteria

paroxysmal or early persistent (max. 3 months) atrial fibrillation
scheduled for PVI-only catheter ablation

Exclusion Criteria

long-standing persistent atrial fibrillation
previous left atrial ablation
claustrophobia preventing CMR
sever renal insufficiency (GFR >30 ml/min)
gadolinium contrast allergy
presence of implantable devices not compatible with magnetic resonance
pregnancy and lactation
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