Exercise Capacity Before and After AF Ablation in Patients With HFpEF

  • STATUS
    Recruiting
  • End date
    Dec 30, 2023
  • participants needed
    34
  • sponsor
    University of Vermont
Updated on 24 May 2022
ejection fraction
fibrillation

Summary

In a prospective, observational pilot study of patients scheduled for an atrial fibrillation (AF) ablation at the University of Vermont Medical Center the investigators will compare exercise capacity before and four months after AF ablation.

Description

Patients ≥ 18 years of age who are scheduled for an AF ablation at the University of Vermont Medical Center will be screened for the following inclusion criteria: H2FpEF score of ≥ 6 (corresponding to ≥90% probability of HFpEF (19)) AND echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50% AND at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea). Exclusion criteria: (1) Life expectancy <12 months, (2) moderate or more valvular disease, (3) inability to walk on a treadmill. Patients with early recurrent AF (defined as AF after a 12-week post-procedural blanking period accounting for post-ablation inflammation) will be withdrawn from the study and not proceed to the 4 month follow up visit.

Details
Condition Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation
Clinical Study IdentifierNCT05376748
SponsorUniversity of Vermont
Last Modified on24 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

H2FpEF score of ≥ 6 (corresponding to >90% probability of HFpEF (19))
echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50%
at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea)
AF ablation scheduled at UVMMC

Exclusion Criteria

Life expectancy <12 months
moderate or more valvular disease
inability to walk on a treadmill
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