Vonoprazan-Based Triple Therapy in Comparison With Extended Sequential Therapy

  • STATUS
    Recruiting
  • End date
    Feb 28, 2025
  • participants needed
    582
  • sponsor
    Fu Jen Catholic University Hospital
Updated on 23 May 2022
amoxicillin
clarithromycin
lansoprazole

Summary

This study aims to compare the efficacy of the current standard first-line anti-helicobacter pylori regimen, extended proton pump inhibitor-based sequential therapy, with that of vonoprazan-based triple therapy, through a randomized controlled trial.

Description

Helicobacter pylori infection is a well-established risk factor for peptic ulcer disease and gastric cancer. It's now a consensus of experts that H.pylori infection should be treated once it is recognized. Extended proton pump inhibitor (PPI)-based sequential therapy as one of the most commonly used first-line regimens provides a satisfactory eradication rate of 90.7% (95% CI, 87.4% - 94.0%). Nevertheless, its complexity of the "sequential" usage is sometimes confusing to the patients and may lead to treatment failure. The emerging new regimen - vonoprazan-based triple therapy, on the other hand, is another appealing choice with simplicity, short treatment duration, and low pill burden. However, there's still no evidence regarding the use of vonoprazan-based triple therapy with high-dose amoxicillin (1000mg twice daily) as the first-line regimen. This study aimed to compare the efficacy of the current standard first-line regimen, sequential therapy, with that of vonoprazan-based triple therapy with high-dose Amoxicillin.

Details
Condition Helicobacter Pylori
Treatment Vonoprazan-based triple therapy, Extended sequential therapy
Clinical Study IdentifierNCT05371249
SponsorFu Jen Catholic University Hospital
Last Modified on23 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with H.pylori infection who was over 20 years old and agree to participate in the trial will be recruited

Exclusion Criteria

Who had received helicobacter pylori eradication before
Who are known to be allergic to any drug used in this trial
Pregnant women
Who are refuse to participate in the trial for any reason
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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