Valuation in Depressed Mood, Anhedonia, and Anxiety

  • End date
    Jul 2, 2026
  • participants needed
  • sponsor
    Virginia Polytechnic Institute and State University
Updated on 2 June 2022


This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.


This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Condition Neurobehavioral Components of Reward and Loss Valuation
Treatment Cognitive behavioral therapy, valuation with instruction, valuation without instruction
Clinical Study IdentifierNCT05384158
SponsorVirginia Polytechnic Institute and State University
Last Modified on2 June 2022


Yes No Not Sure

Inclusion Criteria

mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games

Exclusion Criteria

history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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