Pericapsular Nerve Group (PENG) Block Combined With Periarticular Multimodal Drug Injection (PMDI) Versus Isolated PMDI for Pain Management After Total Hip Arthroplasty: a Randomized Controlled Trial

  • End date
    Dec 13, 2023
  • participants needed
  • sponsor
    Yonsei University
Updated on 18 May 2022


Adequate pain control after total hip arthroplasty is crucial for early ambulation and patient satisfaction. However, there is no consensus about optimal pain control after post operation. In general, the periarticular multimodal durg injection block has been done for pain control in primary total hip arthroplasty. The pericapsular nerve group (PENG) block has been recently introduced a new technique for blockade of the articular branches of the femoral, obturator and accessory obturator nerves. PENG block is possible to provide sufficient analgesia and preserve lower limb muscle strength. The investigators will compare PENG and PMDI block with isolated PMDI block in patients undergoing total hip arthroplasty.

Condition Total Hip Arthroplasty, Postoperative Pain
Treatment Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI), isolated periarticular multimodal drug injection (PMDI)
Clinical Study IdentifierNCT05320913
SponsorYonsei University
Last Modified on18 May 2022


Yes No Not Sure

Inclusion Criteria

Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective unilateral total hip arthroplasty

Exclusion Criteria

Allergy or intolerance to any of the drugs used in the study
Hepatic or renal insufficiency
Opioid dependency
Pre-existing neurologic or anatomic deficits in the lower extremities
Severe psychiatric illness
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