Non-invasive Liquid Biopsy Analysis of Epigenomics Signatures in Multiple Cancer Types
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- STATUS
- Recruiting
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- End date
- Sep 13, 2023
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- participants needed
- 6500
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- sponsor
- Bluestar Genomics Inc.
Summary
Bluestar Genomics is developing a test from whole blood for the early detection of multiple cancers. The goal of this study is to employ genomics, epigenomics and proteomics methodology for the detection of cancer signal in the blood of subjects with solid tumors. The study will include subjects without cancers that will be followed up every 6-months for up to 3-years from blood draw.
Description
Epigenomic changes in cancer cells can provide a rich source of biomarker signals for the detection of disease. As cancer cells manifest their epigenomic changes in blood due to cell death, DNA and protein molecules can be probed using specific molecular analytic approaches. Bluestar Genomics employs epigenomic technologies to measure dynamic changes in DNA demethylation events via direct measurement of 5-hydroxymethyl-cytosine residues in cfDNA. Companion assays are also run to provide information on cfDNA digestion patterns and protein-based changes in plasma. This information, combined in a machine learning framework, enable the provision of prediction models that report on the presence of cancer and the determination of the tissue of tumor origin. This study will build predictive models and test performance of these models to detect the presence of cancer and tissue of origin in several cancer type by using a matched case-control study design.
Details
| Condition | Diagnosis of Cancer of Various Organs |
|---|---|
| Treatment | Blood draw |
| Clinical Study Identifier | NCT03869814 |
| Sponsor | Bluestar Genomics Inc. |
| Last Modified on | 16 May 2022 |
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