Identifying Prognostic Variables for Persistent Upper Limb Dysfunctions After Breast Cancer Treatment (UPLIFT-BC)

  • STATUS
    Recruiting
  • End date
    Feb 14, 2025
  • participants needed
    250
  • sponsor
    KU Leuven
Updated on 14 May 2022
mastectomy
axillary lymph node dissection
sentinel node
breast-conserving surgery

Summary

Breast cancer is the most frequently occurring cancer, assuming that it accounts for 29% of all new cancers in women (European Cancer Information System). The number of long-term survivors is increasing rapidly due to improving accuracy of the detecting methods, the early diagnosis and advances in cancer treatment.

The International Consortium for Health Outcomes Measurement Initiative described upper limb (UL) function as the health outcome that matters most for breast cancer survivors (BCS). 50% of BCS at 6 months post-radiotherapy suffer from of decreased UL function, i.e. difficulties in performing activities of daily living with the upper limb. Patients experiencing UL dysfunctions and other problems are less likely to be physically active. Given that physical inactivity is associated with an increased risk of mortality after breast cancer, taking away the barriers to physical activity (e.g. UL dysfunctions) is very important. Identifying these factors contributing to chronic UL dysfunction is important in terms of identifying targets for prospective evaluation and specific treatment approaches at specific time points during breast cancer treatment.

There is a need to rethink the follow-up strategy (besides the treatment of the cancer itself) and develop a clinical care pathway consisting of multifactorial screening instruments to identify women and men who are in need of extra rehabilitation efforts and specific rehabilitation goals to alleviate symptoms and side effects experienced by breast cancer survivors. This clinical care pathway should cover all aspects of the International Classification of Function, Disease and Health (ICF), a biopsychosocial framework that conceptualizes a person's level of functioning and bodily structures, activity and participation and contextual factors (including personal and environmental factors).

The present study aims to identify the factors, during and after breast cancer treatment, contributing to persistent Upper Limb (UL) dysfunctions.

Details
Condition Breast Cancer
Treatment assessment of UL function and prognostic factors
Clinical Study IdentifierNCT05297591
SponsorKU Leuven
Last Modified on14 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients scheduled for surgery (mastectomy or breast conserving surgery; in combination with axillary lymph node dissection or sentinel node biopsy) for unilateral primary breast cancer or patients with oligometastatic breast cancer
Patients who receive adjuvant radiotherapy
Patients with a cognitive and language functioning enabling coherent Dutch communication between the examiner and the participant
Patients who can comply with the protocol at baseline assessment and willing to provide written informed consent

Exclusion Criteria

BCS with widespread distance metastases, previous breast surgery, or planned bilateral surgery
And/or with a diagnosis of a neurological or rheumatological condition, diabetes
And/or BCS who are not available the entire duration of the study
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