Effects of Blueberries in Older Adults (BnD)

  • End date
    Jul 11, 2023
  • participants needed
  • sponsor
    Beth Israel Deaconess Medical Center
Updated on 11 July 2022
Accepts healthy volunteers


This randomized, parallel-design trial will evaluate specific clinical and physiological effects of whole blueberries in adults 70 years of age or older at a congregate-living facility.


Although much is already known about the benefits of a healthy diet for the prevention of a wide range of chronic diseases, including the particular health benefits of anthocyanin-rich foods, these effects have been examined with much less frequency in older adults, who tend to be excluded from formal feeding studies and, until recently, have represented a small proportion of ongoing cohort studies. The proposed study will randomize approximately 46 women and 24 men, representative of the proportion of elderly women and men in the U.S., living at Hebrew SeniorLife-affiliated retirement communities in Massachusetts to consume

  1. 1 cup of frozen blueberries daily for 12 weeks


2. 2-3 dried dates daily for 12 weeks.

Dates were chosen as a control food because they contain negligible polyphenols, proportionately high caloric content, and a convenient form for storage. After the 12-week intervention, researchers will repeat in-person study assessments from baseline.

Condition Blood Pressure, Orthostatic Hypotension, Vascular Diseases
Treatment Blueberry Consumption, Dried Date Consumption
Clinical Study IdentifierNCT05358210
SponsorBeth Israel Deaconess Medical Center
Last Modified on11 July 2022


Yes No Not Sure

Inclusion Criteria

years old
Independent-living residents of Hebrew SeniorLife-affiliated facilities
Resident of facility for at least 3 months

Exclusion Criteria

Cardiovascular event or procedure within 3 months of randomization
AHA Class III-IV heart failure
Intolerance or allergy to blueberries or dates
History of gastric bypass surgery
Any planned hospitalization or vacation in the ensuing 4 months
Any current cancer treatment
End-stage renal disease
Any organ transplant
Uncontrolled diabetes mellitus with hemoglobin A1c >9%
Systolic blood pressure >200 mmHg
Inability to provide personal informed consent (e.g. cognitive impairment)
Investigator concern
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