PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS (PRODIGIOUS)

  • End date
    Mar 18, 2024
  • participants needed
  • sponsor
    University Hospital, Brest
Updated on 26 May 2022
glucocorticoid therapy


To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy. In patients with inflammatory rheumatic disorders requiring prolonged glucocorticoid therapy, such tool could be useful to adapt first-line treatment decisions (in daily practice and in future clinical trials). The main objective of the study is to identify routine clinical, biological and DXA baseline characteristics predictive of the occurrence of clinically relevant complications of glucocorticoid therapy at 1 year, in order to propose a predictive score.

Condition Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies, ANCA Associated Vasculitis, Systemic Autoimmune Disease
Clinical Study IdentifierNCT04664465
SponsorUniversity Hospital, Brest
Last Modified on26 May 2022


Yes No Not Sure

Inclusion Criteria

Life expectancy > 1 year
Indication to initiate prolonged glucocorticoid therapy at a dosage ≥ 15 mg/day for the treatment of an inflammatory rheumatic disease
Initial treatment or relapse
Previsional treatment duration > 3 months

Exclusion Criteria

Unable to consent
Previous corticosteroid therapy in the last 3 months at a significant dosage (> 5 mg per day)
Clear my responses

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