Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Chang Gung Memorial Hospital
Updated on 12 May 2022


In the proposed study, we will apply Prevena on the surgical wound right after closure of the wound in the operating theater. Prevena will be used for 7 days, unless there is ongoing infection or much wound drainage that requires debridement.

Most periprosthetic joint infections are from hematogenous origin. Hence, it is considered clean wound unless there is a discharging sinus.

Condition Wound Heal, Periprosthetic Joint Infection
Treatment Prevena Incision Management system
Clinical Study IdentifierNCT05357287
SponsorChang Gung Memorial Hospital
Last Modified on12 May 2022


Yes No Not Sure

Inclusion Criteria

patients with periprosthetic joint infection
indicated for debridement surgery
high risk for wound complication, including one of the followings: diabetes mellitus, use anticoagulants other than aspirin, current smoker, on immunomodulators or steroids, malnutrition, liver disease, renal failure, BMI > 35 kg/m2

Exclusion Criteria

previous flap surgery on the indexed joint
younger than 18 years of age
silver allergy
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