Reduced-dose Versus Standard Dose Radiotherapy for Nasopharyngeal Carcinomain
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- STATUS
- Recruiting
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- End date
- Apr 1, 2026
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- participants needed
- 380
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- sponsor
- Sun Yat-sen University
Summary
To study the 2-year PFS (progression-free survival) of patients with stage II-III nasopharyngeal carcinoma treated with induction chemotherapy followed by two different doses of intensity modulated radiation therapy plus concurrent cisplatin chemotherapy
Description
To explore the 2 year PFS of patients with stageII-III nasopharyngeal carcinoma treated with induction chemotherapy followed by reduced-dose radiotherapy and cisplatin versus standard dose radiotherapy plus cisplatin concurrent chemotherapy. The enrolled patients will receive 2 cycles of cisplatin-based induction chemotherapy, if radiographic CR/PR and EBV DNA=0 after induction chemotherapy, the patients will be randomised assigned to received 60 Gy IMRT combined with 3 cycles of cisplatin concurrent chemotherapy or 70Gy IMRT combined with 3 cycles of cisplatin concurrent chemotherapy.
Details
| Condition | Nasopharyngeal Carcinoma |
|---|---|
| Treatment | IMRT, induction chemotherapy, cisplatin concurrent chemotherapy |
| Clinical Study Identifier | NCT05304468 |
| Sponsor | Sun Yat-sen University |
| Last Modified on | 11 May 2022 |
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