A Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis (Ocarina II)

  • STATUS
    Not Recruiting
  • End date
    Feb 22, 2025
  • participants needed
    232
  • sponsor
    Hoffmann-La Roche
Updated on 29 July 2023
corticosteroids
methylprednisolone
disease or disorder
ocrelizumab

Summary

This study will evaluate the pharmacokinetics, pharmacodynamics, safety, immunogenicity, and radiological and clinical effects of subcutaneous (SC) administration of ocrelizumab compared with the intravenous (IV) infusion of ocrelizumab in patients with either relapsing multiple sclerosis (RMS) or primary progressive multiple sclerosis (PPMS).

Details
Condition Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Treatment Ocrelizumab IV, Ocrelizumab SC, Methylprednisolone IV, Diphenhydramine IV, Dexamethasone given orally, Desloratadine given orally
Clinical Study IdentifierNCT05232825
SponsorHoffmann-La Roche
Last Modified on29 July 2023

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