Efficacy of tACS for Treatment of Auditory Hallucinations in Refractory Schizophrenia

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Tianjin Anding Hospital
Updated on 9 May 2022
auditory hallucinations


The aim of this study is to evaluate the feasibility and efficacy of transcranial alternating current stimulation (tACS) as an add-on treatment for auditory hallucinations in refractory schizophrenia. Meanwhile, we aim to evaluate the effect of tACS on cognitive function of schizophrenia patients. we hypothesize tACS would improve refractory auditory hallucination symptoms in schizophrenia by regulating the gamma frequency band of temporal lobe。


This is a randomized, double-blind, sham-controlled study to detect the effect of tACS for treatment of refractory auditory hallucinations in schizophrenia. 66 participants were randomly assigned 1:1 to tACS group or sham-control group. For both active and sham group, daily tACS sessions were scheduled in a 5-day sequence for four consecutive weeks, and each session lasted 20minutes. Based on the original and stable medication, active participants were administered 2 mA alternating current delivered with gamma frequency, delivered over the temporal lobe, while controls received sham stimulations with the same protocol. Scale assessments are performed at baseline, week 2, week 4 and week 6. Collection of blood took place at baseline, week 4 and week 6.

Condition Schizophrenia
Treatment Transcranial alternating Current Stimulation (tACS)-active, Transcranial Alternating Current Stimulation (tACS)-sham
Clinical Study IdentifierNCT05282329
SponsorTianjin Anding Hospital
Last Modified on9 May 2022


Yes No Not Sure

Inclusion Criteria

Eligible participants aged 18-70 with DSM-5-defined schizophrenia or schizophrenia-like disorder
Duration of illness > 12 weeks
Being clinically stable and on an adequate therapeutic dose of antipsychotics for at least 8 weeks prior to enrolment
Junior high school education or above
After treatment with ≥ 2 different antipsychotics (greater than the equivalent dose of chlorpromazine 600mg), the curative effect was poor (CGI ≥ 4 points or the PANSS score reduction rate since this treatment was less than 20%)
Agreement to participate in the study and provide the written informed consent

Exclusion Criteria

Having unstable medical conditions, current psychiatric comorbidity or active substance use disorder (in exception to caffeine and/or tobacco)
Having Serious physical diseases or nervous system diseases
Having any brain device / implant, including cochlear implant and aneurysm clip
Having a history or family history of autoimmune diseases or immune diseases
Pregnancy or breastfeeding at enrollment
Skin lesions on scalp at the area of electrode application
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note