Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Institute of Liver and Biliary Sciences, India
Updated on 9 May 2022
thrombocytopenic purpura


This project is a pilot randomized controlled trial aimed at investigating the potential of Carica Papaya Leaf Extract, available in a marketed pill formulation, in increasing platelet counts in live donor liver transplant recipients. Carica Papaya leaf extract has shown positive results in increasing platelet counts in various medical conditions such as Dengue, Immune thrombocytopenic purpura and chemotherapy induced thrombocytopenia. Thrombocytopenia i.e. low platelet counts are a common occurrence in patients with chronic liver disease undergoing live donor liver transplant. It has been observed in previous studies that live donor liver transplant recipients who have persistent thrombocytopenia have significantly worse outcomes as compared to patients who have higher platelet counts. Positive results in this study lead to further studies in assessing the impact of platelet augmentation in live donor liver transplant recipients.

Condition Thrombocytopenia
Treatment Placebo, Carica Papaya Leaf Extract
Clinical Study IdentifierNCT05360134
SponsorInstitute of Liver and Biliary Sciences, India
Last Modified on9 May 2022


Yes No Not Sure

Inclusion Criteria

All consenting adults who are planned to undergo live donor liver transplant with platelet counts less than or equal to 75000/μL preoperatively

Exclusion Criteria

Patients who do not consent
Pediatric transplant recipients
Allergic to papaya
Preoperative platelet counts >75,000/ μL
Recent history of DVT
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