Exercise to Boost Response to Checkpoint Blockade Immunotherapy

  • STATUS
    Recruiting
  • End date
    May 10, 2024
  • participants needed
    32
  • sponsor
    H. Lee Moffitt Cancer Center and Research Institute
Updated on 10 October 2022
carcinoma
vaccination
pembrolizumab
nivolumab
ipilimumab
targeted therapy
immunomodulator
immunologic adjuvant

Summary

30 minutes of moderate exercise on an arm ergometer, a cycle ergometer, or a treadmill prior to each administration of standard of care checkpoint blockade immunotherapy across all cycles

Details
Condition Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma
Treatment Walking, Checkpoint Blockade, Immune, Excerise
Clinical Study IdentifierNCT05358938
SponsorH. Lee Moffitt Cancer Center and Research Institute
Last Modified on10 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age ≥ 18 years
Able to read and speak English fluently
Capable of giving informed consent
Patient has received a complete COVID-19 vaccination series
Reported ability to complete 20-30 minutes moderate exercise per positive response to "can you currently walk unaided for six minutes or more?
Scheduled for first-time checkpoint blockade immunotherapy with avelumab, cemiplimab, ipilimumab, nivolumab, or pembrolizumab in the absence of other therapies (e.g. targeted therapy)
Melanoma patients (adjuvant setting)
Melanoma patients (neoadjuvant setting)
cuSCC patients (neoadjuvant setting)
Merkel cell carcinoma patients (neoadjuvant setting)

Exclusion Criteria

Presence of medical conditions, such as severe cardiovascular disease for which an exercise intervention may not be warranted
Presence of major postoperative complications for which an exercise intervention may not be warranted
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