Exercise to Boost Response to Checkpoint Blockade Immunotherapy

  • End date
    May 10, 2024
  • participants needed
  • sponsor
    H. Lee Moffitt Cancer Center and Research Institute
Updated on 10 October 2022
targeted therapy
immunologic adjuvant


30 minutes of moderate exercise on an arm ergometer, a cycle ergometer, or a treadmill prior to each administration of standard of care checkpoint blockade immunotherapy across all cycles

Condition Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma
Treatment Walking, Checkpoint Blockade, Immune, Excerise
Clinical Study IdentifierNCT05358938
SponsorH. Lee Moffitt Cancer Center and Research Institute
Last Modified on10 October 2022


Yes No Not Sure

Inclusion Criteria

Age ≥ 18 years
Able to read and speak English fluently
Capable of giving informed consent
Patient has received a complete COVID-19 vaccination series
Reported ability to complete 20-30 minutes moderate exercise per positive response to "can you currently walk unaided for six minutes or more?
Scheduled for first-time checkpoint blockade immunotherapy with avelumab, cemiplimab, ipilimumab, nivolumab, or pembrolizumab in the absence of other therapies (e.g. targeted therapy)
Melanoma patients (adjuvant setting)
Melanoma patients (neoadjuvant setting)
cuSCC patients (neoadjuvant setting)
Merkel cell carcinoma patients (neoadjuvant setting)

Exclusion Criteria

Presence of medical conditions, such as severe cardiovascular disease for which an exercise intervention may not be warranted
Presence of major postoperative complications for which an exercise intervention may not be warranted
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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