Comparative Study Between the Efficacy of The Serratus Anterior Plane Block and Lumbar Intrathecal Fentanyl Injection for Postoperative Analgesia After Modified Radical Mastectomy

  • STATUS
    Recruiting
  • End date
    Apr 1, 2023
  • participants needed
    50
  • sponsor
    Sohag University
Updated on 17 May 2022

Summary

Modified radical mastectomy (MRM) is one of the most common surgeries performed, and one that may be associated with significant acute postoperative pain in breast surgery. Acute postoperative pain is an independent risk factor in the development of chronic post-mastectomy pain .

Various regional anesthetic procedures have been tried to provide better acute pain control and, consequently, less chronic pain. They can reduce perioperative opiates requirement and thereby decreasing their possible side effects. These regional procedures include local wound infiltration, lumbar intrathecal fentanyl injection, thoracic epidural, thoracic paravertebral block (PVB), and ultrasound (US)-guided interfascial plane blocks. Currently, Ultrasound (US)-guided interfascial plane blocks have been recommended as safe, easy, and reliable alternatives to the use of thoracic epidural and paravertebral blocks in providing analgesia for patients about to undergo breast surgery.

Serratus anterior plane block (SAPB) is one of the Ultrasound (US)-guided interfascial plane blocks, it blocks the intercostal nerves II-VI by injection above or below the serratus muscle in the mid-axillary line and spares the pectoral nerves.

We assumed that SAPB could safely provide a better analgesic profile with an opioid-sparing effect than Intrathecal fentanyl. We will perform this study to evaluate this assumption.

Details
Condition Patients Undergoing Modified Radical Mastectomy
Treatment serratus anterior plane block, Lumbar Intrathecal Fentanyl Injection
Clinical Study IdentifierNCT05352282
SponsorSohag University
Last Modified on17 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

patients with American Society of Anesthesiologists (ASA) grade I to II, 18 to 60 years of age scheduled for Modified Radical Mastectomy surgery

Exclusion Criteria

Patient refusal
Patient with significant neurological , psychiatric or neuromuscular disease
Alcoholism
Drug abuse
Pregnancy or lactating women
Suspected Coagulopathy
Morbid obesity
Known allergy to study medications
Septicaemia and local infection at the block site
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