Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study (VNS-EPS) (VNS-EPS)

  • STATUS
    Recruiting
  • days left to enroll
    58
  • participants needed
    10
  • sponsor
    Northwell Health
Updated on 22 September 2022

Summary

The Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study is a single center, pilot, prospective study that aims at evaluating the effects of auricular vagus nerve stimulation (aVNS) on the human cardiac conduction system.

Description

The Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study is a single center, pilot, prospective study that aims at evaluating the effects of auricular vagus nerve stimulation (aVNS) on the human cardiac conduction system. In this study, we will enroll 10 healthy individuals presenting to the electrophysiology laboratory for an electrophysiological study (EPS). Patients will undergo a standard EPS with 4 catheters (coronary sinus catheter, His catheter, right ventricular catheter, and right atrial catheter). Following the standard EPS, patients will be hooked up a Parasym device to provide transcutaneous electrical stimulation to the auricular branch of the vagus nerve.

Details
Condition Neuromodulation
Treatment Auricular Vagal Nerve Stimulation
Clinical Study IdentifierNCT05350150
SponsorNorthwell Health
Last Modified on22 September 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Primary indication for EPS for the evaluation of cardiac conduction system or supraventricular tachycardia

Exclusion Criteria

Previous EPS with ablation
Previous failed ablation
Known conduction system disease, right or left bundle branch block on EKG
Pregnant women
History of postural orthostatic tachycardia syndrome
Patients who have had prior cervical vagotomy
Patients with skin on the tragus that is broken or cracked
Patients with a history of baseline cardiac disease or atherosclerotic cardiovascular disease, including congestive heart failure (CHF), known severe coronary artery disease or recent myocardial infarction (within 5 years) and patients diagnosed with narrowing of the arteries (carotid atherosclerosis)
Patients with an active implantable medical device, such as a cardiac pacemaker, hearing aid implant, or any implanted metallic, implanted vagus nerve stimulator or electronic device
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