The Function of PET Molecular Imaging Targeting Fibroblast Activation Protein in the Hepatobiliary Malignancies

  • STATUS
    Recruiting
  • days left to enroll
    31
  • participants needed
    80
  • sponsor
    Zhongnan Hospital
Updated on 16 May 2022

Summary

Patients with high clinical suspicion of hepatobiliary malignancies should undergo PET/CT examination with two imaging agents, 68Ga-FAPI (fibroblast activation protein inhibitor) and 18F-FDG within one week, and collect tumor tissue. Finally, the PET/CT results were compared with the pathology report to evaluate the role of 68Ga-FAPI PET/CT imaging in the diagnosis of hepatobiliary malignancies

Description

Patients with high clinical suspicion of hepatobiliary malignancies should undergo PET/CT examination with two imaging agents, 68Ga-FAPI (fibroblast activation protein inhibitor) and 18F-FDG within one week. After comprehensive clinical evaluation, if the patient can be treated with surgery, surgery will be performed, and the patient's pathological specimens will be collected after surgery ; If the patient has no possibility of surgery, ultrasound-guided needle biopsy is performed, and biopsy specimens are collected. Finally, the PET/CT results were compared with the pathology report to evaluate the application value of 68Ga-FAPI PET/CT imaging in the diagnosis and staging of hepatobiliary malignant tumors, and to analyze the guiding significance for the treatment decision of hepatobiliary malignant tumors.

Details
Condition Hepatobiliary Diseases
Treatment 68Ga-FAPI-04 imaging agent
Clinical Study IdentifierNCT05264688
SponsorZhongnan Hospital
Last Modified on16 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Voluntarily participate and sign a written informed consent
18-80 years old (inclusive) male or female
Patients with high clinical suspicion of hepatobiliary malignancy in combination with medical history and imaging studies, etc
Those who obtained pathological diagnosis results through needle biopsy or surgical resection
Have willingness and ability to participate in all research procedures

Exclusion Criteria

Women who are pregnant or breastfeeding
Those who are known to be allergic to the imaging agent 68Ga-FAPI or its excipients
Those who have a history of other malignant tumors in the past
Before the injection of 18F-FDG, the fasting blood glucose level exceeds 11.0mmol/L
Patients with claustrophobia
Those who cannot tolerate lying down for 15-30 minutes
The researchers believe that it is not suitable to participate in this clinical trial
Those who have participated in clinical trials or are participating in other clinical trials within the past month
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