A Triple-targeted Cell Preparation Targeting CD19/CD20/CD22 in Patients With Relapsed/Refractory B-cell Acute Lymphocytic Leukemia
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- STATUS
- Recruiting
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- End date
- Jul 19, 2026
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- participants needed
- 34
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- sponsor
- Institute of Hematology & Blood Diseases Hospital
Summary
A phase I, open-label clinical study to evaluate the safety, tolerability, and efficacy of LCAR-AIO, a triple-targeted cell preparation targeting CD19/CD20/CD22, in patients with relapsed/refractory B-cell acute lymphocytic leukemia
Description
This is an open-label, dose escalation/expansion study to assess the safety, tolerability, and efficacy of LCAR-AIO in patients ≥ 18 years of age with relapsed or refractory B-cell acute lymphocytic leukemia. Patients who meet the eligibility criteria will receive a single dose of LCAR-AIO infusion. The study will include the following sequential phases: screening, pre-treatment (cell product preparation; lymphodepleting chemotherapy), treatment and follow up.
Details
| Condition | Acute Lymphocytic Leukemia |
|---|---|
| Treatment | LCAR-AIO Cells |
| Clinical Study Identifier | NCT05292898 |
| Sponsor | Institute of Hematology & Blood Diseases Hospital |
| Last Modified on | 19 June 2022 |
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