Role of Proton Pump Inhibitors on the Postoperative Course Following Pancreaticoduodenectomy

  • End date
    Jul 31, 2025
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 15 May 2022
disease or disorder


The purpose of this study is to prospectively determine the effects of administering proton pump inhibitors (PPIs) following pancreaticoduodenectomy on postoperative outcomes. The findings of this study will help in avoiding the widespread use of PPIs during the immediate postoperative period following pancreatic surgery.

Condition Pancreatic Cancer, Pancreas Cancer, Ampullary Cancer, Pancreas Neuroendocrine Tumor, Pancreatitis, Distal Extrahepatic Cholangiocarcinoma, Duodenal Cancer
Treatment Placebo, Pantoprazole
Clinical Study IdentifierNCT05251233
SponsorWashington University School of Medicine
Last Modified on15 May 2022


Yes No Not Sure

Inclusion Criteria

All consecutive patients who will undergo pancreaticoduodenectomy with gastric/biliary reconstruction performed as definitive management for a benign or malignant disease at Washington University/Barnes-Jewish Hospital
At least 18 years of age
Ability to understand and willingness to sign an IRB approved written informed consent document

Exclusion Criteria

<18 years of age
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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