Effects of Newly-created Individualized Upper Airway Muscle Functional Training on Patients With OSA

  • STATUS
    Recruiting
  • End date
    May 1, 2025
  • participants needed
    300
  • sponsor
    First Hospital of China Medical University
Updated on 14 May 2022

Summary

Objectives: To observe the effect of newly-created individualized upper airway muscle functional training on the condition and intraday symptoms of OSA patients; to study the effect of this training method on the excitability of the genioglossus muscle cortex; to analyze the factors affecting the efficacy of upper airway training in the treatment of OSA and screening suitable population for upper airway training: Design: A randomized double-blind controlled trial. SAS 9.3 statistical software (SAS Institute, Cary, North Carolina, USA) was used to generate a random number table, and the selected patients were randomly divided into experimental group 1, experimental group 2, and control group according to the ratio of 1:1:1 with 100 cases each.

Unit: Shenyang, China Participants: Consecutive specific OSA patients, who are potential candidates for the treatment of upper airway training (n=300), will be recruited from a sleep center or respirologists, psychiatrists, otolaryngologists and dentists practicing with broad inclusion criteria (age: 20-75 years, AHI:15-50/h; BMI<40 kg/m2).

Interventions: The three groups of subjects completed 7-day functional training and control training of upper airway muscles in different modes, respectively completed polysomnography, neck circumference, Berlin questionnaire and Epworth sleepiness scale before and after training, The genioglossus myoelectric activity was measured after transcranial magnetic stimulation and the excitability of the genioglossus cortex motor center was used to determine the efficacy of different training. After regression analysis, the factors affecting the efficacy of upper airway muscle group training were analyzed to screen the OSA patient population suitable for upper airway muscle group training.

Details
Condition Obstructive Sleep Apnea, Muscle Disorder
Treatment New individualized upper airway muscle functional training
Clinical Study IdentifierNCT05346705
SponsorFirst Hospital of China Medical University
Last Modified on14 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Recent diagnosis of OSA (AHI>15 events/h) announced by a sleep recording
Mean oxygen saturation >90%
Must be able to complete the training

Exclusion Criteria

Inability to tolerate overnight polysomnography in sleep lab
>50% of observed sleep apneas being central
Other sleep disorders such as insomnia, narcolepsy, chronic sleep deficiency, periodic limb movement disorder or restless legs syndrome
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