A Phase 2/3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Subjects Aged 18 Years and Older With APOL1-mediated Proteinuric Kidney Disease

  • End date
    Jun 25, 2026
  • participants needed
  • sponsor
    Vertex Pharmaceuticals Incorporated
Updated on 25 October 2022


The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics (PK) of VX-147 in participants aged 18 years and older with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

Condition Proteinuric Kidney Disease
Treatment Placebo, VX-147
Clinical Study IdentifierNCT05312879
SponsorVertex Pharmaceuticals Incorporated
Last Modified on25 October 2022


Yes No Not Sure

Inclusion Criteria

APOL1 genotype of G1/G1, G2/G2, or G1/G2
Proteinuric kidney disease

Exclusion Criteria

Solid organ or bone marrow transplant
Uncontrolled hypertension
Diagnosis of diabetes mellitus
Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply
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