CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Peking University
Updated on 1 May 2022
invasive breast cancer
core needle biopsy


This is a prospective, single-center, non-randomized, non-controlled observational study.


Almost 55-62% of patients with triple-negative or human epidermal growth factor receptor 2 (HER2) positive, node-positive breast cancer achieve an axillary pathologic complete remission (pCR) after neoadjuvant chemotherapy (NAC). To avoid surgery post-NAC, it is paramount to accurately identify patients who achieve pCR in axillary lymph node (ALN). We found that patients with normal-appearing lymph nodes on computed tomography (CT) based radiomics of the axilla after chemotherapy had a lower risk of developing residual nodal disease. However, the features of CT-based radiomics for pCR ALN following NAC has not been established yet. This study aimed to assess the performance of CT-based radiomics in evaluating the response and predicting pCR of metastatic lymph nodes after NAC in breast cancer patients.

Condition Triple-negative Breast Cancer, HER2-positive Breast Cancer
Clinical Study IdentifierNCT04457700
SponsorPeking University
Last Modified on1 May 2022


Yes No Not Sure

Inclusion Criteria

Triple-negative or HER2-positve invasive breast cancer with axillary lymph node metastasis by confirmed by fine needle aspiration or core needle biopsy
Underwent computed tomography for assessment of axillary lymph node status before and after neoadjuvant chemotherapy
Attend the study voluntarily, sign the informed consent

Exclusion Criteria

Contradiction for adjuvant chemotherapy
Contradiction for proceeding surgery
Clear my responses

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