Cannabidiol on Reward- and Stress-related Neurocognitive Processes in Individuals With Opioid Use Disorder

  • days left to enroll
  • participants needed
  • sponsor
    Brigham and Women's Hospital
Updated on 10 August 2022


The purpose of this study is to determine the impact of cannabidiol on reward- and stress-related neurocognitive processes among individuals with opioid use disorder on buprenorphine or methadone treatment.


Individuals with opioid use disorder (OUD) demonstrate reward- and stress-related neurocognitive changes compared to individuals without OUD, including cravings for opioids in response to exposure to triggers, tendency to make impulsive and disadvantageous decisions, and a strong attentional bias towards drug-related cues. Together, these deficits are significant contributors to relapse and discontinuation of treatment. Cannabidiol (CBD) has been shown to impact some of these cognitive deficits but studies of CBD among individuals with OUD are mostly lacking. Therefore, this study aims to answer whether CBD has any impact on reward-related neurocognitive deficits in individuals with OUD. If successful, this line of research will lay the groundwork for future studies to evaluate CBD's impact on OUD treatment outcomes.

Condition Opioid-use Disorder
Treatment Placebo, Cannabidiol 100 MG/ML [Epidiolex]
Clinical Study IdentifierNCT04982029
SponsorBrigham and Women's Hospital
Last Modified on10 August 2022


Yes No Not Sure

Inclusion Criteria

English speaking
DSM5 diagnosis of opioid use disorder
Receiving buprenorphine or methadone for treatment of opioid use disorder
Agreeable to abstaining from using any cannabis or CBD products for the duration of the trial

Exclusion Criteria

Any self-reported use of cannabis or CBD products in the past 30 days
Baseline depression (PHQ9) or anxiety (GAD7) scores of greater than 10
Currently pregnant
Hepatic liver enzymes greater than 3x upper normal limit
Hypersensitivity to cannabinoids or sesame oil (CBD solution comes in sesame oil emulsion)
Currently taking any medications with known significant pharmacokinetic interactions with CBD
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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