A Study of TQB2450 Injection Plus Chemotherapy Followed by TQB2450 Plus Anlotinib Versus Tislelizumab Plus Chemotherapy Followed by Tislelizumab in the Treatment of First-line Non-squamous Non-small Cell Lung Cancer(NSCLC).

  • STATUS
    Recruiting
  • End date
    Dec 10, 2023
  • participants needed
    390
  • sponsor
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Updated on 10 May 2022

Summary

This is Phase 3, randomized, open-label, parallel controlled study designed to compare the efficacy and safety of TQB2450 in combination with platinum-containing chemotherapy followed by TQB2450 plus Anlotinib versus tislelizumab in combination with platinum-containing chemotherapy followed by tislelizumab in locally advanced (stage ⅢB/ⅢC), metastatic or recurrent ( Stage IV) non-squamous NSCLC cancer. The primary endpoint is Progression Free Survival (PFS) assessed by IRC.

Details
Condition Advanced Non-squamous Non-small Cell Lung Cancer
Treatment TQB2450 injection, Tilelizumab injection, Anlotinib hydrochloride capsule, Pemetrexed disodium injection, Carboplatin injection
Clinical Study IdentifierNCT05346952
SponsorChia Tai Tianqing Pharmaceutical Group Co., Ltd.
Last Modified on10 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

According to the 8th edition of the International Association for the Study of Lung Cancer and the American Joint Committee on Cancer Classification, the TNM staging of lung cancer is locally advanced (stage ⅢB/ⅢC), metastatic or recurrent ( Stage IV) NSCLC patients
Between the ages of 18-75 years (calculated based on the date of signing ICF); male or female; Eastern cooperative oncology group (ECOG) score 0-1; estimated survival time ≥ 3 months
According to the RECIST 1.1 standard, there is at least one measurable lesion. If the measurable lesion is located in the radiotherapy area, it should be clearly defined as a progressive state
Patients who have not received systemic anti-tumor therapy for advanced, recurrent or metastatic diseases in the past. For those who have received adjuvant chemotherapy in the past, the interval between the recurrence time and the last adjuvant chemotherapy should be at least 6 months; The interval between the end of previous radiotherapy for chest and this treatment should be more than 6 months, and the interval between palliative radiotherapy for chest and this treatment should be more than 7 days
Tumor tissue sections that have not undergone radiotherapy at or after the diagnosis of advanced or metastatic NSCLC must be provided. Tumor tissue samples must be archived samples or freshly obtained samples within 12 months before randomization
For non-squamous NSCLC, patients with no EGFR sensitive mutations, ALK fusion, ROS1 fusion
The function of main organs are well and meet the following standards
a. Routine blood examination standards (without blood transfusion or correction with hematopoietic stimulating factor drugs within 14 days before screening): i. Absolute neutrophil count (ANC) ≥1.5×109 /L; ii. Platelets ≥100×109 /L; iii. Hemoglobin ≥90 g/L. b. The blood biochemical examination shall meet the following standards: i. Total bilirubin (TBIL) ≤ 2 × upper limit of normal (ULN) (Patients with Gilbert syndrome ≤ 3 × ULN); ii. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST)≤2.5×ULN. If it is accompanied by liver metastasis, ALT and AST≤5×ULN; 8.iii. Serum creatinine (Cr) ≤1.5×ULN or creatinine clearance estimated by Cockcroft-Gault glomerular filtration formula ≥60 mL/min; iv. Serum albumin (ALB) ≥30g/L. c. Urine routine examination standard: urine routine indicates urine protein <++; if urine protein ≥++, it is necessary to confirm that the 24-hour urine protein quantitative ≤1.0 g. d. Blood coagulation test standards: prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR)≤1.5×ULN (no anticoagulant therapy). e. Thyroid Stimulating Hormone (TSH) ≤ ULN; if abnormal, T3 and T4 levels should be examined. If T3 and T4 levels are normal, it can be selected. f. Heart color Doppler ultrasound assessment: Left ventricular ejection fraction (LVEF) ≥50%. g. 12-lead ECG evaluation: QTc<450ms (male), QTc<470ms (female)
Women of childbearing age should agree to use effective contraceptive measures during the study period and 6 months after the end of the study, and have a negative serum pregnancy test within 7 days before the study enrollment; men should agree to the study period and 6 months after the end of the study period Effective contraceptive measures must be used internally
The subjects voluntarily joined the study, signed the informed consent form, and had good compliance

Exclusion Criteria

Tumor disease and medical history
Brain metastases without local treatment; Note: Subjects who have previously received brain metastasis therapy and meet all the following criteria can participate in this study: i. Only supratentorial and cerebellar metastases; ii. The condition needs to be stable for ≥4 weeks and no new brain metastases or brain metastases are found Expanded imaging evidence; iii. The subject must have stopped corticosteroids/dehydrator for at least 2 weeks before starting to use the trial drug
There are midbrain, pons, medulla oblongata, spinal cord and meningeal metastases;
Other malignant tumors appeared or were present within 3 years. The following two cases can be included: other malignant tumors treated by single operation have achieved 5-year Disease-free survival (DFS) in a row; The cured cervical carcinoma in situ, non melanoma skin cancer and superficial bladder tumor [ta (non-invasive tumor), tis (carcinoma in situ) and T1 (tumor infiltrating basement membrane)]
Central type, cavity squamous cell carcinoma (primarily in the main bronchus and around the hilar);Imaging shows that the tumor invades large blood vessels or is unclearly separated from the blood vessels, or the investigator judges that the tumor is likely to invade important blood vessels and cause fatal bleeding during the subsequent study(The major vessels in the chest include pulmonary aorta, left pulmonary artery, right pulmonary artery, four pulmonary veins, superior vena cava, inferior vena cava and aorta)
Severe bone injury caused by tumor bone metastasis, including pathological fracture of weight-bearing bone and spinal cord compression that occurred within 6 months or is expected to occur in the near future(Such as spine, pelvis, femur, tibia, phalanges, calcaneus, etc.)
Patients with serous cavity (thoracic cavity, abdominal cavity, or pericardial cavity) that require repeated drainage to relieve clinical symptoms (as determined by the investigator), or who have received drainage of serous cavity effusion for the purpose of treatment within 2 weeks before treatment
Previous anti-tumor treatments
Received the treatment of proprietary Chinese medicines with anti-tumor indications specified in the NMPA approved drug instructions within 2 weeks before the start of the study treatment(Including compound cantharidin capsules, Kangai injection, Kanglaite capsule/injection, Aidi injection, brucea javanica oil injection/capsule, Xiaoaiping tablet/injection, Huachansu capsule, etc.)
Previously received related immunotherapy drugs for programmed death 1 (PD-1), PD-L1, cytolytic T lymphocyte-associated antigen-4 (CTLA-4), etc
Previous use of anti-angiogenic drugs such as bevacizumab, anlotinib, apatinib, lenvatinib, sorafenib, sunitinib, regorafenib, fruquintinib, etc
Patients who have been vaccinated with immunomodulatory drugs within 30 days before starting treatment(Such as interleukin-2, thymosin, lentinan, etc.)
Failure to recover from the toxicity and/or complications of previous interventions to CTCAE ≤1, except for hair loss and peripheral neuropathy ≤2
Combined diseases and medical history
Liver cirrhosis, active hepatitis _;(Note: active hepatitis (hepatitis B reference: HBV-DNA > 1_103 copy /mL or > 2000IU/mL) when HBsAg is positive. Hepatitis C reference: HCV antibody is positive, and HCV titer detection value exceeds the upper limit of normal value)
Renal abnormalities: i.Renal failure requires hemodialysis or peritoneal dialysis; ii.Previous or existing nephrotic syndrome, chronic nephritis
Cardiovascular and cerebrovascular abnormalities: i.Patients with previous or present heart failure, degree II or above heart block: ii.Myocardial infarction or unstable angina, supraventricular or ventricular arrhythmia with clinical significance need treatment or intervention; iii.Vascular embolism and cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage and cerebral infarction) occurred within 9 months( Prophylactic use of anticoagulant therapy is allowed for patients with thrombotic tendency or undergoing anticoagulant therapy.) iv.After more than two kinds of drug treatment, blood pressure control is still not ideal (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 90 mmHg)
Gastrointestinal abnormalities: i.Inability to take medications (such as inability to swallow, intestinal obstruction, etc.); ii.A history of malabsorption syndrome or other diseases that interfere with gastrointestinal absorption; iii.Received treatment for active peptic ulcer in the past 6 months; iv.Despite the maximum medical treatment, chronic diarrhea of grade 2 and above continues to occur; v.Other conditions determined by the researcher that may cause gastrointestinal bleeding and perforation
History of immunodeficiency
i.Have a history of immunodeficiency, including HIV positive or other acquired or
congenital immunodeficiency diseases; ii.Active autoimmune disease or history of
autoimmune disease, including but not limited to Crohn's disease, ulcerative colitis
autoimmune hepatitis/enteritis/vasculitis/nephritis, etc
iii.Prepare to undergo or have previously received an organ transplant; iv.Patients who
require systemic or topical immunosuppressive therapy to achieve immunosuppressive purposes
and need to continue to use them within two weeks before randomization (except for
glucocorticoid daily dose <10 mg prednisone or other equivalent hormones)
Note: Hormone replacement therapy (such as thyroxine, insulin, or physiological
corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not
considered as systemic therapy and allowed to be used
f. Bleeding risk: i.Suffered from bleeding or coagulopathy within 28 days before the start
of treatment or was using warfarin, aspirin and other antiplatelet agglutination drugs
(except for aspirin ≤100 mg/d preventive drugs); ii.Had hemoptysis >2.5 mL/day in 28 days
before the start of treatment; iii.Regardless of the severity, patients with any history of
bleeding or coagulopathy; iv.Received major surgical treatment, open biopsy, etc. within 28
days before the start of the study treatment; v.Long-term unhealed wounds or fractures
except for pathological fractures; g. Poor control of type I diabetes or II diabetes
(fasting blood glucose (FBG)> 10mmol/L); h. Severe infections within 4 weeks before the
start of study treatment, including but not limited to hospitalization due to bacteremia
severe pneumonia, or other severe infections; subjects with ≥ grade 2 active infections
within 4 weeks before the start of study treatment Or fever of unknown cause occurred
during the screening period and before the first administration>38.0℃; i. Past or existing
pneumoconiosis, interstitial pneumonia, (non-infectious) pneumonia that requires adrenal
corticosteroid therapy, currently suffering from other types of pneumonia ≥2, or lung
function tests confirmed severely impaired lung function (Forced Expiratory Volume in the
first second (FEV1) or diffusing capacity of lung for carbon monoxide(DLCO) or DLCO per
alveolar volume (DLCO /VA) accounts for the expected value %<40%) and other objective
evidence; j. Patients with active tuberculosis within 1 year before enrollment; subjects
with a history of active pulmonary tuberculosis infection 1 year ago must provide clear
evidence of cure before enrollment; if tuberculosis is suspected during the screening
period, chest radiographs and sputum must be passed Enter the group only after the liquid
and clinical symptoms are eliminated; k. Allergies, or a history of severe allergies in the
past, or severe hypersensitivity reactions after receiving other monoclonal antibody
treatments, or known allergies to the ingredients of the study drug excipients; l. Previous
history of severe mental disorders; m. People with a history of drug abuse, alcohol or drug
abuse
The end of the previous clinical study (last dose) is less than 4 weeks or the study
drug's 5 half-lives, whichever is shorter
Live attenuated vaccine vaccination history within 28 days before randomization or
planned live attenuated vaccination during the study period. Seasonal influenza
vaccine for injection is usually an inactivated virus vaccine and is allowed to be
vaccinated during the study period
Female patients during pregnancy or lactation
According to the investigator's point of view, it may increase the risks associated
with participating in the study, or other severe, acute or chronic medical diseases or
laboratory abnormalities that may interfere with the interpretation of the study
results, or other reasons that are not suitable for participating in this clinical
study
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