Urinary Tract Infections in Cirrhosis

  • STATUS
    Recruiting
  • End date
    Apr 5, 2024
  • participants needed
    35
  • sponsor
    Gomel State Medical University
Updated on 29 April 2022

Summary

Evaluate the prevalence and types of urinary tract infections, the features of the gut and urinary tract microbiota in cirrhosis, to assess its importance in the development of complications and outcomes of cirrhosis.

Description

Asymptomatic bacteriuria in an individual without urinary tract symptoms is defined by a mid-stream sample of urine showing bacterial growth > 105 cfu/mL in two consecutive samples in women and in one single sample in men. A complicated urinary tract infections occurs in an individual in whom factors related to the host (e.g. underlying diabetes or immunosuppression) or specific anatomical or functional abnormalities related to the urinary tract. Laboratory urine culture is the recommended method to determine the presence or absence of clinically significant bacteriuria.

Catheter-associated urinary tract infections refers to urinary tract infections occurring in a person whose urinary tract is currently catheterised or has been catheterised within the past 48 hours. Signs and systemic symptoms compatible with сatheter-associated urinary tract infections include new onset or worsening of fever, rigors, altered mental status, malaise, or lethargy with no other identified cause, flank pain, costovertebral angle tenderness, acute haematuria, pelvic discomfort and in those whose catheters have been removed dysuria, urgent or frequent urination and suprapubic pain or tenderness. Microbiologically, сatheter-associated urinary tract infections is defined by microbial growth of > 103 cfu/mL of one or more bacterial species in a single catheter urine specimen or in a mid-stream voided urine specimen from a patient whose urethral, suprapubic, or condom catheter has been removed within the previous 48 hours.

Details
Condition Liver Cirrhosis, Urinary Tract Infections
Treatment 16S rRNA gene sequencing
Clinical Study IdentifierNCT05335213
SponsorGomel State Medical University
Last Modified on29 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

clinical diagnosis of cirrhosis

Exclusion Criteria

human immunodeficiency virus or acquired immune deficiency syndrome
autoimmune diseases
oncology
organ transplantation
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