The Role of Stress Neuromodulators in Decision Making Under Risk (Part II) (SID2)

  • STATUS
    Recruiting
  • End date
    Mar 31, 2023
  • participants needed
    60
  • sponsor
    Charite University, Berlin, Germany
Updated on 27 April 2022
Accepts healthy volunteers

Summary

The aim of the proposed project is to combine precise pharmacological manipulation of the noradrenergic system with behavioral modeling of memory processes, and fMRI methods to study the effect of a pharmacologically induced blockade of the noradrenergic system on memory processes. Behaviorally, the investigators will focus on the effect of the noradrenergic blockade on working memory performance, and recognition memory.

Description

Affective states like acute stress can influence cognition, i.e., memory processes. Physiologically, acute stress elicits an array of autonomic and endocrine responses, including a fast release of norepinephrine from the locus coeruleus noradrenergic (LC NA) system. Compelling evidence shows that in healthy humans, stimulation of the noradrenergic system increases memory performance whereas noradrenergic blockade reduces memory performance. Functional magnetic resonance imaging (fMRI) studies have shown that manipulations of the noradrenergic system affects responsiveness and connectivity within networks that are important for autonomic-neuroendocrine control and temporal and spatial attention orientation. So far, no study investigated the neural underpinnings of memory processes after a pharmacologically induced noradrenergic blockade. The aim of the proposed project is to combine precise pharmacological manipulation of the noradrenergic system with behavioral modeling of distinct memory processes, and fMRI methods to study the effect of a pharmacologically induced blockade of the noradrenergic system on two distinct memory processes. Behaviorally, the investigators will focus on the effect of the noradrenergic blockade on working memory performance, and recognition memory. Participants are randomly assigned to one of two groups: (A) clonidine, or (B) placebo.

Details
Condition Stress
Treatment Placebo, Clonidin
Clinical Study IdentifierNCT05318248
SponsorCharite University, Berlin, Germany
Last Modified on27 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

right handed, high-school diploma

Exclusion Criteria

former & present DSM-5 axis I disorders, medication
Clear my responses

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