Role of Toilet Bronchoscopy in RICU

  • STATUS
    Recruiting
  • End date
    Jul 27, 2023
  • participants needed
    130
  • sponsor
    Assiut University
Updated on 27 April 2022
COPD
chest x-ray
x-rays
chronic obstructive pulmonary disease
pulmonary disease
oximetry
asthma
fibrosis
bronchiectasis
bronchoscopy
assisted ventilation
fiberoptic bronchoscopy

Summary

Toilet bronchoscopy is a potentially therapeutic intervention to aspirate retained secretions within the endotracheal tube and airways and revert atelectasis. Aspiration of airway secretions is the most common indication to perform a therapeutic bronchoscopy in the intensive care unit (ICU) .

Toilet bronchoscopy is particularly beneficial when retained secretions are visible during the procedure and when air-bronchograms are not present at the chest radiograph. It is also beneficial when there is an indication to reverse lobar atelectasis, rather than simply to remove accumulated mucus.

Toilet bronchoscopy is used in lobar and complete lung collapse in mechanically ventilated patients who fail to respond to treatments such as physiotherapy or recruitment manoeuvres.

The success rates (defined as radiographic improvement on chest X-ray [CXR] or an improved PaO2/PAO2 ratio) in the ICU patient population had.

Patients with acute hypoxaemic respiratory failure may already be on non-invasive ventilation (NIV), or require NIV preemptively for Fiberoptic Bronchoscopy (FB). These patients should be considered high risk for requiring intubation post-procedure; therefore, Fiberoptic Bronchoscopy should be performed by an experienced operator in a setting allowing facilities to safely secure the airways. NIV with early therapeutic FB rather than mechanical ventilation can help avoid intubation and reduce tracheostomy rate. Hospital mortality, duration of ventilation, and hospital stay remain similar

Description

Aim Of Work To study the value of toilet bronchoscopy in

  1. Mechanical ventilated patients with chest disease and copious secretion.
  2. Mechanical ventilated patients diagnosed to have atelectasis radiologically.
  3. Patients on non-invasive ventilation with chest diseases and copious secretion
  4. Compare Different types of mucolytics during toilet bronchoscopy in mechanically ventilated patients.
  5. Compare Different types of sedations during toilet bronchoscopy in mechanically ventilated patients.

Details
Condition COPD, Asthma, Cystic Fibrosis
Treatment toilet bronchoscope
Clinical Study IdentifierNCT04798118
SponsorAssiut University
Last Modified on27 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

• Patients on mechanical ventilation with underlying dieases that are characterized with mucus overproduction such as asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, and cystic fibrosis
Patients on mechanical ventilation with visible large amount of sputum during suction in order to clear secretions
Patients on mechanical ventilation with radiologically diagnosed atelectasis and absent air-bronchograms
Patient on NIV who was benefit from toilet bronchoscopy to clear retained secretion

Exclusion Criteria

Absolute contraindications
Absence of consent from the patient or his/her representative
Inability to adequately oxygenate the patient during the procedure
Current myocardial ischaemia
Significant haemodynamic instability
Life-threatening cardiac arrhythmias
Current significant bronchospasm
Undrained pneumothorax
Relative contraindications
Thrombocytopenia (platelet count ≤50,000 platelets/mm)
INR of 2 or greater, or an elevated PTT
BUN >30\
severe tracheal obstruction
Recent myocardial ischaemia and/or unstable angina
Intracranial hypertension
Poorly-controlled heart failure
Recent oral intake
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note