Surgery or Chemoradiotherapy for Cervical Esophageal Cancer

  • End date
    Dec 31, 2028
  • participants needed
  • sponsor
    Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Updated on 5 May 2022


To compare surgery with definitive chemoradiotherapy for patients with resectable cervical esophageal squamous cell carcinoma.

Condition Cervical Esophageal Cancer
Treatment Esophagectomy
Clinical Study IdentifierNCT05327517
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences
Last Modified on5 May 2022


Yes No Not Sure

Inclusion Criteria

Patients with resectable cervical esophageal squamous cell carcinoma (cT1b-T4aN0-3M0)
Cervical esophageal cancers spreads upwards to involve the hypopharynx and downwards to involve the thoracic esophagus can also be included
Aged 18-75 years
Without any contraindication of operation
Hemoglobin >=90 g/L; Leukocytes >=4.0x10^9/L; Absolute neutrophil count >=1.5x10^9/L; Platelet >=100x10^9/L;Total bilirubin <=1.5 ULN; ALT <=2.5 ULN; AST <=2.5 ULN; Serum creatinine <=1.5 ULN or creatinine clearance rate >=50 mL/min (Cocheroft-Gault);INR <=1.5 ULN; APTT <=1.5 ULN
Without other malignancies
Expected R0 resection
Volunteered to participate in the study, signed the informed consent form

Exclusion Criteria

Without other malignancies
With mental diseases
With hemorrhagic disease
Inoperable patients
Pregnant or lactating women
Has a history of allergy to paclitaxel or cisplatin
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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