Molecular Biomarkers for Sepsis

  • STATUS
    Recruiting
  • End date
    Oct 26, 2023
  • participants needed
    400
  • sponsor
    University Hospital, Basel, Switzerland
Updated on 26 April 2022
pneumonia
fever

Summary

This multi-center observational case-control study in Intensive Care Unit (ICU) patients is to identify novel biomarkers allowing to recognize severe community acquired pneumonia (sCAP) -associated sepsis at an earlier stage and predict sepsis-related mortality. Patients with sCAP (cases) will be profoundly characterized over time regarding the development of sepsis and compared with control patients. The mechanisms and influencing factors on the clinical course will be explored with most modern -omics technologies allowing a detailed characterisation. These data will be analysed using machine learning algorithms and multi-dimensional mathematical models.

Details
Condition Sepsis, Severe Community-acquired Pneumonia (sCAP), Infection, Bacterial
Treatment compare data patterns by data-driven algorithms to determine sepsis, compare data patterns by data-driven algorithms to predict sepsis-related mortality
Clinical Study IdentifierNCT04280354
SponsorUniversity Hospital, Basel, Switzerland
Last Modified on26 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Admission to the ICU of one of the participating centers
Cases: severe community acquired pneumonia with requirement for ICU admission
Controls: Clinical phenotype of inflammation not due to suspected sepsis In addition, control patients will be patients with fever >38°C, CRP >100mg/L, no infection focus expected in ≥ 24h
All required sample types can most likely be collected within the first 24h visits
Expected ICU stay of more than 24h

Exclusion Criteria

Admission to the hospital within the prior 14 days
Patients with psychosis
Evidence of a hospital acquired pneumonia
One of the following respiratory conditions: Acute exacerbation of chronic obstructive pulmonary disease (COPD) or bronchiectasis, acute severe asthma, aspiration pneumonia, tuberculosis, clinical suspected viral pneumonia without bacterial infection, cardiogenic pulmonary oedema
Patients with an acute respiratory distress Syndrome (ARDS)
Patient which can be managed as outpatients and do not require an ICU
Patient where a transmission to another institution is likely within the next 24h
Documented rejection of the general consent or participation to research in general
Patients with a palliative situation and a life expectancy due to other diseases (e.g. progressed cancer) less than 28 days
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