Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy

  • End date
    Feb 1, 2026
  • participants needed
  • sponsor
    Ohio State University
Updated on 12 July 2022
suicide prevention
Accepts healthy volunteers


The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes. Specifically, male and female adults with current suicidal intent will be randomly assigned to receive either a 1-hour session of crisis response planning (CRP) or a 1-hour session of standard crisis risk management (Treatment as Usual). The effects of both conditions on changes in emotion regulation, behavioral inhibition, stress reactivity, and suicide risk will be evaluated post-intervention and at six-month follow-up. Additional assessments of changes in mood and suicidality will be collected daily during the first 10-days following intervention, and then monthly for a duration of six months. A cohort of healthy controls is included in the study but are not randomized to either treatment condition. The investigators hypothesize the following: 1) A single session of CRP will acutely change suicide risk and 2) Individuals who receive CRP will show sustained improvements in measures of suicidality when compared to individuals who received the Treatment as Usual intervention.

Condition Suicide
Treatment TAU, CRP
Clinical Study IdentifierNCT05275101
SponsorOhio State University
Last Modified on12 July 2022


Yes No Not Sure

Inclusion Criteria

Generally medically and neurologically healthy
Age 18 years or older at the time of consent
Willing and able to give informed consent
Individuals in the acutely suicidal group: endorse current suicide intent as indicated by a total score of 5 or greater on the Beck's Scale for Suicidal Ideation

Exclusion Criteria

Medical or neurologic condition or neurocognitive dysfunction that would interfere with the study
Current or past manic/hypomanic episode, schizophrenia, or psychotic symptoms
Deafness in either ear
Currently pregnant or trying to become pregnant
Electroconvulsive therapy (ECT) within the past 6 months
Current moderate to severe substance use disorder
Lack of fluency in English
Positive alcohol breathalyzer test and/or acute drug intoxication the day of the fMRI scans
Unwilling or unable to sign the informed consent document
Under 18 years old at the time of enrollment
Traumatic brain injury from a suicide attempt or another event
Presence of ferrous-containing metals within the body
Inability to tolerate small, enclosed spaces without significant anxiety
Individuals enrolled as controls: no lifetime history of any DSM-5 disorder
Individuals enrolled as controls: no lifetime history of suicide ideation or intent
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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